一对十二岁的双胞胎男孩Zack(DylanSprouse)和Cody(ColeSprouse)还有他们的妈妈是这所波斯顿高档Tipton酒店的长期住客。在这里，他们认识了新朋友London(BrendaSong)和Maddie(AshleyTisdale)。Zack和Cody接二连三的恶作剧把Tipton旅馆变成了他们的游乐场。在搞笑、捣蛋、引发混乱的同时，也带着London和Maddie疯了一回。
Outrageousshenanigansensuewhen12-year-oldtwinboysZack(DylanSprouse)andCody(ColeSprouse)turntheupscaleBostonhotelwheretheylive(TheTipton)intotheirownpersonalplayground.LivinginasuitewiththeirmomCarey,theboysoftentaketheirnewfriendsLondonandMaddiealongfortheride,astheycausemischief,mayhem,andvariouscatastrophesintheirelegantnewdigs.
